Taming Immune and Inflammatory Responses to Treat Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Immune and inflammatory mechanisms of atherosclerosis (*).
Atherosclerosis is an inflammatory disease of the wall of large- and medium-sized arteries that is precipitated by elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Although dendritic cells (DCs) and lymphocytes are found in the adventitia of normal arteries, their number is greatly expanded and their distribution changed in human and mouse atherosclerotic arteries. Mac...
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Viral lower respiratory tract infection (LRTI) can lead to severe disease at all ages, but with the exception of influenza vaccination, prevention is not available for most respiratory viruses, hence, effective, disease-limiting therapy is urgently required. To enable the development of novel effective therapeutic approaches, we need to improve understanding of the pathological mechanisms of vi...
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With high global chronic disease burden [1] and prevalence [2], mental illness is presently facing an enormous drug development challenge. In stark contrast to revolutionary, mostly serendipitous, discovery of psychiatric drugs between the end of 1940's and late 1950's, followed by a period of stagnancy during the next half a century, the last decade has witnessed drug development pipeline for ...
متن کاملImmune and inflammatory mechanisms in the development of atherosclerosis.
Investigations over the past 10 years have shown that the immune system is involved in the development of atherosclerosis. There is evidence for an inflammatory process in the vessel wall and also for an involvement of specific immunological mechanisms in atherogenesis. The data can be summarised as follows: (a) immunoglobulins as well as T lymphocytes and macrophages are found in large numbers...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2018
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2017.10.081